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Updated: Jun 12, 2026
Demonstrating a Multi-drug Resistant Mycobacterium tuberculosis Amplification Microarray
Published on: April 25, 2014
First national survey of Mycobacterium tuberculosis drug resistance, Madagascar, 2005-2006
H Ramarokoto1, O Ratsirahonana, J L Soares
1National Tuberculosis Programme Madagascar, Department of Tuberculosis and Leprosy Control, Ministry of Health and Family Planning, Antananarivo, Madagascar. herimana@pasteur.mg
Setting:
A national survey of Mycobacterium tuberculosis resistance was conducted for the first time in Madagascar between October 2005 and July 2007.
Objective:
To determine resistance rates among new and previously treated cases of pulmonary tuberculosis.
Methods:
In a cluster sampling representative of the general population of the country, 1275 smear-positive tuberculosis patients recruited at 34 sites, 926 new patients and 87 previously treated patients underwent drug susceptibility testing against rifampicin (RMP), isoniazid (INH), streptomycin and ethambutol on Löwenstein-Jensen medium using the indirect proportion method.
Results:
Resistance among new cases was 6.5% (95%CI 4.9-8) and among previously treated cases it was 11.5% (95%CI 4.8-18.2). Monoresistance among new cases was 5.8% (95%CI 4.2-7.3), mainly to INH (3.7%). Multiresistance to INH and RMP was 0.2% (95%CI 0-0.5) among new cases and 3.4% (95%CI 0-7.2) among previously treated cases. No significant difference was noted with regard to sex or age.
Conclusion:
The rates of resistance among new and previously treated cases remain relatively low in Madagascar.
