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Updated: Jun 12, 2026
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New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals
Published on: May 30, 2013
IL-35, an anti-inflammatory cytokine which expands CD4+CD25+ Treg Cells
Summary
Interleukin-35 (IL-35) is a cytokine that expands regulatory T cells and suppresses effector cells. This suggests IL-35 as a potential therapy for inflammatory and autoimmune diseases.
Area of Science:
- Immunology
- Molecular Biology
- Cell Biology
Background:
- Interleukin 12 (IL-12) family cytokines, including IL-35, are critical regulators of T helper cell differentiation and immune responses.
- IL-35 is formed by the EBI3/p35 heterodimer and plays a role in inflammation, immunity, and tissue proliferation.
Discussion:
- IL-35 expands CD4+CD25+ regulatory T cells (Tregs) and suppresses effector T cell proliferation.
- IL-35 is constitutively expressed by Tregs and contributes to their suppressive function, promoting IL-10 and TGF-beta generation.
Key Insights:
- IL-35 inhibits Th17 cell polarization, a key pathway in autoimmune diseases.
- IL-35 promotes CD4+CD25+ T cell proliferation and the generation of anti-inflammatory cytokines IL-10 and TGF-beta.
Outlook:
- IL-35 represents a novel therapeutic target for chronic inflammatory and autoimmune disorders.
- Further research into IL-35's mechanisms could lead to new treatments for immunological diseases.
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