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Updated: Jun 12, 2026

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin
Published on: March 26, 2015
Remyelination in the chicken sciatic nerve
M A Hanwell1, N A Cooper, A D Kidman
1Neurobiology Unit, School of Life Sciences, New South Wales Institute of Technology, Dunbar Building, Wesbourne Street, Gore Hill, N.S.W. 2065 Australia.
Abstract:
Remyelination in the chicken sciatic nerve occurring after the injection of diphtheria toxin was studied. The rates of fast axonal transport and conduction velocities were measured sixty days after the injection of the toxin. Fast axonal transport rates were found to have returned to normal in the remyelinated nerves, but conduction velocity was markedly reduced even though the birds appeared to walk normally. The remyelinated nerve fibres had on histological examination relatively thin myelin sheaths. Of greater interest was the number of Schmidt-Lanterman clefts observed in both the control and remyelinated nerves when viewed in the electron microscope.
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