Brain polyamines and aggressive behavior of isolated mice

Brain polyamine levels of male Swiss albino mice which had developed aggressive behavior during isolation, did not differ significantly from those of isolated animals which had not developed aggressivity during isolation, or from those of control animals which were housed in groups. Thus we were unable to confirm the results of Tadano (Folia Pharmac. Jap.70, 457-464, 1974) and Tadano et al. (Folia Pharmac. Jap.70, 9-18, 1974) who had reported that mice made aggressive showed an increase of brain spermidine concentration, which paralleled aggressivity, and which returned to normal values when the aggressive behavior was reversed by grouped housing.