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Lipid composition and sphingolipid fatty acids of myelin in fruit bat brain
J van der Westhuyzen1, R C Cantrill
1MRC Brain Metabolism Research Group, School of Pathology of the South African Institute for Medical Research and the University of the Witwatersrand, P.O. Box 1038 Johannesburg 2000, South Africa.
Abstract:
Myelin was isolated from the brain of adult fruit bats (Rousettus aegyptiacus) in a discontinuous sucrose gradient. Cholesterol comprised 189.0 mol/100 mol lipid phosphorus, galactolipids 60.3 mol/100 mol phosphorus and plasmalogens 32.5 mol/100 mol phosphorus. Choline and ethanolamine glycerophosphatide were present in nearly equal amounts followed by serine glycerophosphatide, sphingomyelin and inositol glycerophosphatides. The fatty acid composition of sphingomyelin and non-hydroxy cerebroside was determined by gas-liquid chromatography. Fatty acids were mainly saturated or mono-unsaturated with a small percentage of polyunsaturated fatty acids present. The lipid composition and sphingolipid fatty acid distribution in bat myelin was fairly similar to that of other species.
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