Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spirometry in the Lung Health Study. 1. Methods and quality control.

P L Enright1, L R Johnson, J E Connett

  • 1Mayo Clinic, Rochester, MN 55905.

The American Review of Respiratory Disease
|June 1, 1991
PubMed
Summary

The Lung Health Study ensured high-quality spirometry for smokers by controlling variables, minimizing lung function variability. This rigorous approach supports accurate FEV1 slope measurements for smoking intervention trials.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characteristics of COPD in never-smokers and ever-smokers in the general population: results from the CanCOLD study.

Thorax·2015
Same author

Pulmonary function in an international sample of HIV-positive, treatment-naïve adults with CD4 counts > 500 cells/μL: a substudy of the INSIGHT Strategic Timing of AntiRetroviral Treatment (START) trial.

HIV medicine·2015
Same author

Gaps in using bronchodilators, inhaled corticosteroids and influenza vaccine among 23 high- and low-income sites.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2014
Same author

Exacerbation-like respiratory symptoms in individuals without chronic obstructive pulmonary disease: results from a population-based study.

Thorax·2014
Same author

Restricted spirometry in the Burden of Lung Disease Study.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2012
Same author

Genetic association between human chitinases and lung function in COPD.

Human genetics·2011

Area of Science:

  • Pulmonary Medicine
  • Clinical Trials
  • Respiratory Health

Background:

  • The Lung Health Study is a clinical trial investigating smoking cessation and bronchodilator effects on lung function decline.
  • Accurate spirometry is crucial for detecting changes in FEV1 slope in smokers with airflow limitation.

Purpose of the Study:

  • To evaluate the effectiveness of a spirometry quality control program in minimizing short-term intraindividual FEV1 variability.
  • To ensure reliable FEV1 slope measurements for the Lung Health Study.

Main Methods:

  • Implemented a stringent spirometry testing protocol controlling for participant preparation, maneuver acceptability, technician training, equipment calibration, and result processing.
  • Conducted spirometry on 5,887 smokers aged 35-60 during three screening visits.

Related Experiment Videos

  • Monitored technician performance and conducted site visits to maintain quality.

    • Main Results:

    • Mean intraindividual FEV1 variability was 119 ml in women and 162 ml in men (5.8% coefficient of variation).
    • Over 97.9% of test sessions achieved acceptable FVC maneuvers with reproducible FEV1 values.
    • Site visits and performance monitoring correlated with improved and sustained high-quality spirometry grades.

    Conclusions:

    • The spirometry quality control program successfully minimized short-term intraindividual FEV1 variability.
    • The established protocol ensures the reliability of FEV1 slope measurements, crucial for the Lung Health Study's objectives.
    • Rigorous quality control is essential for the validity of findings in large-scale respiratory clinical trials.