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Updated: Jun 12, 2026

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

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Published on: August 14, 2019

Impaired bladder function in aging male rats.

Weixin Zhao¹, Tamer Aboushwareb, Chanda Turner

¹Wake Forest Institute for Regenerative Medicine, Winston-Salem, North Carolina, USA.

The Journal of Urology

|May 22, 2010

Summary

This summary is machine-generated.

Aging significantly impacts rat bladder function, increasing capacity and residual urine while decreasing muscle response. This animal model helps study age-related bladder changes in humans.

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Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

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Published on: August 9, 2012

Area of Science:

Urology
Gerontology
Animal Models

Background:

Bladder dysfunction prevalence increases with age.
Human studies face challenges separating aging effects from external factors.
Animal models offer a controlled environment to study age-related physiological changes.

Purpose of the Study:

To evaluate the impact of aging on male rat bladder function in vivo and in vitro.
To characterize age-related morphological changes in the rat bladder.
To assess the utility of Fischer/Brown Norway rats as a model for age-related bladder dysfunction.

Main Methods:

Compared young (4-6 months) and old (28-30 months) male Fischer/Brown Norway rats.
Conducted in vivo cystometric studies in conscious, freely moving rats.
Performed in vitro studies on bladder tissue strips, including receptor activation and electrical stimulation, followed by histological examination.

Main Results:

Old rats exhibited higher bladder weight, capacity, post-void residual volume, and frequency.
Micturition pressure decreased in old rats, while baseline and intermicturition pressures increased.
In vitro studies showed reduced bladder strip responses to muscarinic receptor activation and electrical field stimulation in old rats.
Histology revealed urothelial thinning, reduced muscle mass, and increased collagen in older rats' bladders.

Conclusions:

Physiological aging alters male rat bladder function independently of external factors.
Aging leads to increased bladder capacity, residual urine, and spontaneous activity, with diminished contractile responses.
Observed changes in aged rats mirror those in aging human bladders, validating the Fischer/Brown Norway rat as a suitable model.