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A method for serial selective arterial catheterization and digital subtraction angiography in rodents
A Buhalog1, R Yasuda, D Consigny
1Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
AJNR. American Journal of Neuroradiology
|May 22, 2010
Summary
Researchers developed a new method for serial arterial catheterizations and digital subtraction angiography (DSA) in rats. This technique enables repeated imaging in rodent models for extended study periods.
Area of Science:
- Veterinary Radiology
- Medical Imaging
- Rodent Models
Background:
- Digital subtraction angiography (DSA) is crucial for studying rodent disease models.
- Serial intra-arterial examinations are limited in current rodent imaging techniques.
- A method for extended, sequential DSA in rats was lacking.
Purpose of the Study:
- To develop and validate a technique for sequential arterial catheterizations and DSA in rats.
- To enable longitudinal imaging studies in rodent models of human diseases.
Main Methods:
- A transfemoral approach was used in 12 adult male rats.
- Three sequential DSA examinations were performed over 6-8 weeks.
- Each examination involved two selective arterial catheterizations and DSA.
Main Results:
- Ten out of 12 rats completed all three examinations.
- No adverse effects or arterial injuries were observed.
- Image quality remained consistent across serial examinations.
Conclusions:
- The described technique allows for serial arterial catheterizations and DSA in rats.
- This method enhances the utility of rodents in studying human diseases.
- The technique provides a valuable tool for longitudinal imaging research in animal models.
