Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Glomerular Filtration Rate and its Regulation

Glomerular Filtration Rate and its Regulation

The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...

Renal Corpuscle

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...

Glomerular Filtration

Glomerular Filtration

The filtration membrane in the renal system is a highly specialized structure essential for filtering blood. It consists of glomerular capillaries and podocytes, forming a selective barrier that permits the passage of water and small solutes while restricting most plasma proteins and blood cells.
Components of the Filtration Membrane
The filtration process involves three key layers: the glomerular endothelial cells, the basement membrane, and the podocyte-formed filtration slits.

Acute Kidney Injury II: Pathophysiology

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Long-term real-world evidence of sparsentan efficacy in patients with IgA nephropathy treated with SGLT2 inhibitors.

Clinical kidney journal·2026

Same author

Lipoprotein apheresis in the era of new lipid-lowering therapies.

European heart journal·2026

Same author

Iptacopan in IgA Nephropathy - Final 24-Month Data.

The New England journal of medicine·2026

Same author

[AI Application in Nephrological Diagnostics].

Deutsche medizinische Wochenschrift (1946)·2025

Same author

Dipsticks and point-of-care Microscopy in Urinary Tract Infections in primary care: Results of the MicUTI pilot cluster randomised controlled trial.

PloS one·2025

Same author

Treatment persistence, lipid lowering, and 3-year clinical outcomes in patients at very high cardiovascular risk on PCSK9 monoclonal antibodies.

Clinical research in cardiology : official journal of the German Cardiac Society·2025

Search research articles

Related Experiment Video

Updated: Jun 12, 2026

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Published on: March 4, 2022

PDGF-C mediates glomerular capillary repair.

Peter Boor¹, Claudia R C van Roeyen, Uta Kunter

¹Division of Nephrology and Immunology, University Hospital Aachen, Pauwelsstr. 30, D-52074 Aachen, Germany. boor@email.cz

The American Journal of Pathology

|May 22, 2010

Summary

This summary is machine-generated.

Platelet-derived growth factor (PDGF)-C promotes kidney healing by enhancing glomerular endothelial cell repair. PDGF-C infusion accelerated healing in glomerulonephritis and thrombotic microangiopathy models.

More Related Videos

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Published on: November 10, 2021

Isogenic Kidney Glomerulus Chip Engineered from Human Induced Pluripotent Stem Cells

Isogenic Kidney Glomerulus Chip Engineered from Human Induced Pluripotent Stem Cells

Published on: November 4, 2022

Related Experiment Videos

Last Updated: Jun 12, 2026

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Published on: March 4, 2022

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Published on: November 10, 2021

Isogenic Kidney Glomerulus Chip Engineered from Human Induced Pluripotent Stem Cells

Isogenic Kidney Glomerulus Chip Engineered from Human Induced Pluripotent Stem Cells

Published on: November 4, 2022

Area of Science:

Nephrology
Vascular Biology
Cell Biology

Background:

Glomerular endothelial cell injury is central to kidney diseases.
Platelet-derived growth factor (PDGF)-C is known for pro-angiogenic properties, but its renal role is uncharacterized.
Identifying factors that promote glomerular repair is crucial for therapeutic development.

Purpose of the Study:

To investigate the role and therapeutic potential of PDGF-C in kidney injury and repair.
To determine PDGF-C's effects on glomerular endothelial cells in models of glomerulonephritis and thrombotic microangiopathy.

Main Methods:

Administered PDGF-C or its antagonist to rats with mesangioproliferative glomerulonephritis.
Utilized a mouse model of thrombotic microangiopathy.
Examined effects on cultured glomerular endothelial cells.

Main Results:

PDGF-C infusion reduced kidney injury markers (mesangiolysis, microaneurysms) and increased endothelial cell proliferation in glomerulonephritis.
PDGF-C antagonism worsened kidney injury and reduced endothelial cell area.
PDGF-C stimulated fibroblast growth factor-2 expression and had indirect pro-angiogenic effects.

Conclusions:

PDGF-C is a potent pro-angiogenic factor in the kidney.
PDGF-C promotes glomerular endothelial cell repair and capillary healing.
PDGF-C represents a promising therapeutic target for kidney diseases involving endothelial damage.