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Marginal zone B-cell orbital lymphoma with intracranial involvement
Radwan Almousa1, Min-En Nga, Gangadhara Sundar
1Department of Ophthalmology, Ophthalmic Plastic and Reconstructive Surgery, National University Health System, Singapore.
Ophthalmic Plastic and Reconstructive Surgery
|May 22, 2010
Summary
A rare case of orbital marginal zone B-cell lymphoma presented as eyelid swelling and vision loss. This indolent lymphoma extended into the brain, a previously undescribed intracranial association.
Area of Science:
- Ophthalmology
- Oncology
- Neurology
Background:
- Orbital tumors can present with diverse symptoms, impacting vision and ocular motility.
- Marginal zone B-cell lymphoma is an indolent lymphoma, typically extranodal.
- Intracranial involvement is uncommon in orbital lymphomas.
Observation:
- A 40-year-old woman experienced a 2-year history of painless right lower eyelid swelling.
- Ophthalmological examination revealed severe vision loss, hypoglobus, and exotropia in the right eye.
- Computed Tomography (CT) demonstrated a diffuse orbital infiltrative lesion extending into the brain parenchyma.
Findings:
- Histopathology confirmed orbital marginal zone B-cell lymphoma.
- The lymphoma exhibited unusual intracranial extension, a novel finding in the literature.
- This case highlights the potential for indolent lymphomas to manifest with aggressive intracranial spread.
Implications:
- This case expands the known spectrum of orbital marginal zone B-cell lymphoma presentation.
- It underscores the importance of thorough investigation for intracranial extension in orbital lymphomas.
- Further research is needed to understand the mechanisms and clinical significance of intracranial involvement in this lymphoma subtype.
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