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Systemic T-cell lymphoma presenting as an acute nonresolving eyelid mass
Mohammad S Raja1, Deepak Gupta, Richard Y Ball
1Ophthalmology Department, James Paget University Hospitals NHS Foundation Trust, Gorleston, Great Yarmouth, United Kingdom. docraja@hotmail.com
Ophthalmic Plastic and Reconstructive Surgery
|May 22, 2010
Summary
A peripheral T-cell lymphoma, initially presenting as an eyelid cyst, was diagnosed in a 39-year-old man. Successful treatment with chemotherapy and bone marrow transplant led to complete remission, highlighting effective management of this rare ocular adnexal lymphoma.
Area of Science:
- Ophthalmology
- Oncology
- Hematology
Background:
- Ocular adnexal lymphomas are rare malignancies.
- Peripheral T-cell lymphomas (PTCL) can involve extranodal sites, including the orbit and eyelids.
- Early diagnosis and appropriate staging are crucial for effective management.
Observation:
- A healthy 39-year-old man presented with a persistent right upper eyelid cyst.
- The cyst showed no signs of globe or orbital involvement.
- Histopathology confirmed a diagnosis of peripheral T-cell lymphoma, unspecified type, at stage 3.
Findings:
- The patient underwent combination chemotherapy (cyclophosphamide, hydroxydoxorubicin, oncovin, prednisolone) followed by autologous bone marrow transplant.
- He achieved complete remission 24 months posttreatment.
- This case demonstrates a successful treatment outcome for PTCL presenting as an ocular adnexal mass.
Implications:
- This case highlights the importance of considering lymphoma in the differential diagnosis of eyelid masses.
- Effective treatment strategies exist for ocular adnexal PTCL, leading to long-term remission.
- Further research into rare presentations of T-cell lymphomas is warranted to improve diagnostic and therapeutic approaches.