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Updated: Jun 12, 2026

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
Published on: August 17, 2022
Transplantation for acute liver failure: perioperative management
Randolph H Steadman1, Adriaan Van Rensburg, David J Kramer
1Department of Anesthesiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095-7403, USA. rsteadman@mednet.ucla.edu
Purpose Of Review:
A number of conditions can lead to acute liver failure. Determining the cause has important prognostic implications that guide decisions regarding the likelihood of spontaneous recovery, or conversely, the need for transplantation.
Recent Findings:
Neurological deterioration is associated with intracranial hypertension, which requires meticulous management. The decision to employ invasive intracranial pressure monitoring is controversial because of associated risks and the lack of controlled studies. Recent literature addressing the use of intracranial pressure monitoring is reviewed.
Summary:
Even tertiary care units that specialize in liver disease treat acute liver failure patients infrequently. Knowledge of the latest guidelines and treatment protocols can lead to improved patient care.
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