Computer-aided morphometric data collection, mapping, and analysis for neuropathologists

Neurologic diseases are frequently characterized by morphologic changes in neuronal tissue. Neuropathologists evaluate such changes by microscopic examination of brain and other tissues. This paper provides an overview of a microcomputer-based image acquisition and analysis system interfaced to an automated microscope directed at aiding neuropathologists in evaluating neuropathologic alterations. Information is provided on general system architecture and function. Details are provided on measurement techniques, key morphologic parameter calculations, data display, and analysis.