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Related Experiment Video

Updated: Jun 12, 2026

Simulation, Fabrication and Characterization of THz Metamaterial Absorbers
13:44

Simulation, Fabrication and Characterization of THz Metamaterial Absorbers

Published on: December 27, 2012

Terahertz technology: a boon to tablet analysis.

M P Wagh1, Y H Sonawane, O U Joshi

  • 1NDMVPS's College of Pharmacy, Department of Pharmaceutics, Shivajinagar, Gangapur Road, Nashik-422 002, India.

Indian Journal of Pharmaceutical Sciences
|May 22, 2010
PubMed
Summary
This summary is machine-generated.

Terahertz pulse imaging offers a safe, non-destructive method for analyzing pharmaceutical tablet coatings. This technique precisely measures coating thickness, ensuring drug bioavailability and quality control.

Keywords:
Coating uniformityTerahertz pulsed imaging (TPI)film coatingprocess analytical technology (PAT)

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07:28

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Published on: August 30, 2012

Area of Science:

  • Physics and Chemistry
  • Materials Science
  • Pharmaceutical Technology

Background:

  • The terahertz (THz) gap (0.3–10 THz) bridges microwave and infrared frequencies, offering unique spectroscopic and imaging capabilities.
  • THz radiation is non-ionizing, non-destructive, and non-invasive, presenting a safer alternative to X-rays for material analysis.
  • Terahertz spectroscopy provides unique spectral fingerprints for chemical and physical forms, complementing existing techniques like optical imaging and infrared spectra.

Purpose of the Study:

  • To demonstrate the potential of terahertz pulse imaging (TPI) for analyzing pharmaceutical tablet coatings.
  • To highlight TPI's capability in assessing tablet coating integrity and uniformity, crucial for drug bioavailability.
  • To showcase TPI as a method for measuring tablet coating thickness.

Main Methods:

  • Utilizing a dendrimer-based high-power terahertz source and spectroscopy technologies.
  • Applying terahertz pulse imaging for non-destructive, internal chemical analysis of pharmaceutical dosage forms.
  • Illustrating the technique on pharmaceutical tablets to analyze coating thickness.

Main Results:

  • Terahertz imaging provides high certainty regarding the integrity of tablet coatings.
  • The technique effectively assesses the matrix performance of tablet cores.
  • Demonstrated capability of terahertz pulse imaging for precise measurement of tablet coating thickness.

Conclusions:

  • Terahertz pulse imaging is a powerful tool for the non-destructive analysis of pharmaceutical tablets.
  • TPI ensures tablet coating integrity and uniformity, critical for consistent drug bioavailability.
  • This technology offers significant advantages over traditional methods for pharmaceutical quality control.