In situ forming polymeric drug delivery systems

Area of Science:

• Polymer Science
• Drug Delivery Systems
• Biomaterials

Background:

• In situ forming polymeric formulations are liquid solutions that solidify into gels within the body post-administration.
• This transformation facilitates controlled and sustained drug release, overcoming limitations of conventional delivery methods.

Purpose of the Study:

• To provide a comprehensive review of in situ forming polymeric gel systems.
• To discuss their formulation, evaluation, advancements, and commercial applications.

Main Methods:

• Review of existing literature on in situ gel-forming polymers and their characteristics.
• Analysis of factors influencing gelation, including temperature, pH, ions, and UV irradiation.
• Examination of various polymers (e.g., gellan gum, chitosan, PLA, PLGA) and solvents used in formulation.

Main Results:

• In situ gels offer sustained and prolonged drug action, enhanced patient compliance, and reduced administration frequency.
• Gelation can be triggered by various stimuli like temperature modulation, pH changes, or UV irradiation.
• These systems can be administered via multiple routes including oral, ocular, rectal, vaginal, and injectable.

Conclusions:

• In situ forming polymeric gels represent a promising advanced drug delivery technology with significant advantages over conventional systems.
• Their manufacturing process is less complex, reducing investment and production costs.
• Further research and development in this area are expected to yield more sophisticated and effective drug delivery solutions.