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Updated: Jun 12, 2026

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
09:52

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

Published on: March 9, 2018

[Antifungal therapy in special situations: resistant candidiasis and aspergillosis]

R Rabagliati1

  • 1Departamento de Medicina Interna, Pontificia Universidad Catolica de Chile, Santiago, Chile.

Drugs of Today (Barcelona, Spain : 1998)
|May 22, 2010
PubMed

Insights

Invasive fungal infections (IFIs) are a growing concern for cancer patients and transplant recipients. These complex infections lead to worse outcomes, longer hospitalizations, and increased mortality.

Area of Science:

  • Oncology
  • Mycology
  • Infectious Diseases

Context:

  • Oncohematological patients with febrile neutropenia are at high risk.
  • Hematopoietic precursor transplant recipients face increased susceptibility.
  • Invasive fungal infections (IFIs) present significant clinical challenges.

Purpose:

  • To define and highlight the severity of invasive fungal infections (IFIs).
  • To emphasize the impact of IFIs on patient outcomes and healthcare resources.
  • To identify common and emerging fungal pathogens in immunocompromised populations.

Summary:

  • Invasive fungal infections (IFIs) are increasingly prevalent in immunocompromised patients, particularly in oncohematology and transplant settings.
  • Candidiasis and aspergillosis represent the majority of IFIs, while Fusarium and mucormycosis are emerging threats.
  • The term invasive fungal infection (IFI) underscores the associated morbidity, prolonged hospital stays, elevated costs, and mortality risk.

Impact:

  • Improved understanding of IFI burden in vulnerable patient groups.
  • Highlights the need for vigilant diagnosis and management strategies.
  • Informs clinical practice and resource allocation for IFI prevention and treatment.

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