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Diabetes, prediabetes and cancer mortality
X H Zhou1, Q Qiao, B Zethelius
1Department of Public Health, University of Helsinki, PL41, Mannerheimintie 172, Helsinki, Finland.
Diabetologia
|May 22, 2010
Summary
Diabetes and prediabetes significantly increase cancer mortality risk, especially for liver cancer. Cancer deaths rise linearly with higher glucose levels, highlighting a critical link between glucose metabolism and cancer survival.
Area of Science:
- Endocrinology
- Oncology
- Epidemiology
Background:
- Glucose tolerance status is a key indicator of metabolic health.
- Previous research suggests a potential link between diabetes and cancer risk, but comprehensive data on mortality is needed.
Purpose of the Study:
- To investigate the association between glucose tolerance status and cancer mortality risk.
- To determine if prediabetes and diabetes influence overall and specific cancer death rates.
Main Methods:
- Utilized data from 17 European cohorts (DECODE study) with 44,655 participants (26,460 men, 18,195 women).
- Employed Cox proportional hazards analysis, adjusting for multiple risk factors including BMI, cholesterol, blood pressure, and smoking.
- Followed participants for 5.9 to 36.8 years to assess cancer mortality outcomes.
Main Results:
- Prediabetes and diabetes were associated with significantly increased cancer mortality risk in both men and women compared to normal glucose tolerance.
- Elevated risks were observed for specific cancers, including stomach, colon-rectum, and liver cancer in men, and liver and pancreas cancer in women.
- Cancer mortality risk increased linearly with rising fasting and 2-hour plasma glucose concentrations.
Conclusions:
- Diabetes and prediabetes are linked to a higher risk of cancer death.
- Liver cancer mortality showed a particularly strong association with impaired glucose tolerance.
- Glucose concentrations demonstrate a dose-response relationship with overall cancer mortality.
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