Related Experiment Video
Updated: Jun 12, 2026
07:37
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
[Neuroendocrine immune interactions in rheumatic diseases]
1Klinik und Poliklinik für Innere Medizin I, Universitätsklinikum Regensburg, 93042 , Regensburg, Deutschland. rainer.straub@klinik.uni-regensburg.de
Zeitschrift Fur Rheumatologie
|May 22, 2010
Summary
Neuroendocrine mechanisms significantly impact chronic inflammatory and autoimmune diseases. Circadian rhythms and hormone fluctuations influence immune responses, offering potential new therapeutic strategies for rheumatic conditions.
Area of Science:
- Immunology
- Neuroendocrinology
- Rheumatology
Context:
- Clinical observations reveal neuroendocrine system's profound influence on immune responses in chronic inflammatory diseases.
- Factors like pregnancy, sex, hormonal therapies, stress, and circadian rhythms modulate disease activity.
Purpose:
- To explore the intricate interplay between neuroendocrine factors and the immune system in chronic inflammatory and autoimmune diseases.
- To elucidate how hormones and neurotransmitters affect immune cells and disease progression.
Summary:
- Hormones and neurotransmitters influence immune responses through various mechanisms, including immune stimulus, cell types, target organ microenvironment, and timing/concentration of signaling molecules.
- The circadian rhythm of symptoms, peaking in the morning, underscores the neuroendocrine system's role via hormonal and neuronal pathways linking the brain to immune activation.
Impact:
- Understanding these neuroendocrine-immune interactions can pave the way for novel therapeutic strategies targeting rheumatic diseases.
- Highlights the potential for chronotherapy and hormone-based interventions in managing inflammatory conditions.
Related Concept Videos
01:24T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
01:29Autoimmune Disorders
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Concept and Mechanism of Autoimmune Diseases
The immune system...
01:23Rheumatic Heart Disease I: Introduction
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
01:27Psychoneuroimmunology: Cardiovascular Disease
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
01:25Inflammatory Bowel Disease III: Crohn's Disease
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
01:19Psychoneuroimmunology: Diabetes and Cancer
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...