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Response to letter to the editor re. Hines J, Wilkinson SM, John SM, et al. The three moments of skin cream application: an evidence-based proposal for use of skin creams in the prevention of irritant contact dermatitis in the workplace.

Journal of the European Academy of Dermatology and Venereology : JEADV·2016

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The three moments of skin cream application: an evidence-based proposal for use of skin creams in the prevention of irritant contact dermatitis in the workplace.

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Related Experiment Video

Updated: Jun 12, 2026

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

[Skin involvement in zoster].

¹dermprof-Konsultationen, Krefeld, Germany. Dermprof@web.de

Klinische Monatsblatter Fur Augenheilkunde

|May 22, 2010

Summary

This summary is machine-generated.

A shingles vaccine effectively prevents zoster and its painful complications like postherpetic neuralgia (PHN). Vaccination is recommended for older adults to reduce the risk of shingles and associated chronic pain.

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Last Updated: Jun 12, 2026

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

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Published on: December 18, 2012

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1

Published on: August 24, 2015

Area of Science:

Virology
Immunology
Dermatology

Context:

Shingles (zoster) is a painful skin rash caused by varicella zoster virus (VZV) reactivation, primarily affecting older adults and immunocompromised individuals.
Complications include postherpetic neuralgia (PHN), affecting 10-20%, and ocular involvement in 10-25%, leading to chronic pain, scarring, and vision loss.
Current treatments involve antiviral medications and pain management, but efficacy depends on early initiation, often delayed due to non-specific initial symptoms.

Purpose:

To evaluate the efficacy of a live, attenuated varicella zoster virus (VZV) vaccine in preventing shingles and its complications.
To assess the vaccine's impact on the severity and duration of pain, including postherpetic neuralgia (PHN).

Summary:

A live, attenuated VZV vaccine, with potency at least 14 times higher than varicella vaccines, was tested in a large clinical trial.
The vaccine demonstrated over 50% efficacy in preventing shingles.
It was also effective in reducing pain severity and duration, and preventing PHN.

Impact:

Shingles vaccination is recommended for elderly individuals to prevent zoster and its debilitating sequelae.
Widespread vaccination can decrease the incidence of chronic pain conditions like PHN and reduce healthcare burden.
Early intervention through vaccination offers a proactive approach to managing VZV reactivation and its associated health risks.