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Area of Science:

  • Materials Science
  • Biophysics
  • Acoustics

Background:

  • Polymersomes, synthetic vesicles from diblock copolymers, show promise for drug delivery and imaging.
  • Ultrasound is emerging as a therapeutic modality alongside its diagnostic applications.

Purpose of the Study:

  • To investigate the response of nanoscale PEO-b-PBD polymersomes to low-frequency ultrasound (20 kHz).
  • To quantify dye leakage as a measure of polymersome permeation under ultrasound exposure.

Main Methods:

  • Sonication of polymersomes at 20 kHz with varying intensity and duration.
  • Measurement of fluorescent dye leakage from the polymersome core.
  • Size measurements and direct visualization of polymersomes using microscopy.

Main Results:

  • Significant dye leakage occurred above a specific ultrasound intensity threshold, suggesting acoustic cavitation involvement.
  • Ultrasound induced transient poration, not complete vesicle rupture.
  • Leakage extent was inversely related to membrane thickness and directly related to sonication time and intensity.

Conclusions:

  • Ultrasound can controllably permeabilize polymersomes via transient poration.
  • Polymersome membrane properties and ultrasound parameters dictate the extent of permeabilization.
  • Findings support the potential of ultrasound-triggered drug release from polymersomes.