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Synthesis of some 2-benzoxazolinone derivatives and their analgesic properties
H Erdogan1, M Debaert, J C Cazin
1University of Hacettepe, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara, Turkey.
Arzneimittel-Forschung
|January 1, 1991
Abstract:
In this study, eight new 1-(2-benzoxazolinone-6-yl)-2-(4-arylpiperazine-1-yl)ethanol and -propanol derivatives have been prepared. Their structures have been elucidated by IR- and 1H-NMR-spectra and by elementary analysis. The analgesic activities of these compounds, using modified Koster's test have been investigated. 1-(5-Chloro-3-methyl-2-benzoxazolone-6-yl)-2-[4-(2-methoxyphenyl)p iperazine-1- yl]ethanol has been found more active than O-acetyl-salicylic acid, respectively.