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Updated: Jun 12, 2026

Examining the Conformational Dynamics of Membrane Proteins in situ with Site-directed Fluorescence Labeling
Published on: May 29, 2011
Direct observation of electron-transfer-induced conformational transformation (molecular actuation) in a
Ruchi Shukla1, Khushabu Thakur, Vincent J Chebny
1Marquette University, Department of Chemistry, P.O. Box 1881, Milwaukee, Wisconsin 53201-1881, USA.
Abstract:
With the aid of laser-flash photolysis, the one-electron oxidation of conformationally mobile tetramethoxydibenzobicyclo[4.4.1]undecane (1), using photoexcited chloranil as an oxidant, allows us to show that extended 1(+•) undergoes a conformational transformation to π-stacked folded 1(+•) on a microsecond time scale (τ ≈ 1 μs), which is at least six times longer than that found for the conformationally locked model compound.
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