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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

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Related Experiment Video

Updated: Jun 12, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

CRTH2 expression on T cells in asthma.

K Mutalithas1, C Guillen, C Day

  • 1Institute for Lung Health, Department of Infection Immunity and Inflammation, University Hospitals of Leicester, Leicester, UK.

Clinical and Experimental Immunology
|May 25, 2010
PubMed
Summary
This summary is machine-generated.

Prostaglandin D2 receptor CRTH2 is expressed on T cells, particularly those producing IL-4 and IL-13. Despite preferential expression, CRTH2+ T cells are too few to significantly impact asthma pathogenesis.

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Last Updated: Jun 12, 2026

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Assessment of Lymphocyte Migration in an Ex Vivo Transmigration System
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Published on: September 20, 2019

Area of Science:

  • Immunology
  • Allergy and Respiratory Medicine

Background:

  • Mast cell-derived prostaglandin D2 (PGD2) is a key mediator in allergic asthma.
  • PGD2 influences eosinophils and T helper type 2 (Th2) cells via the CRTH2 receptor.
  • CRTH2 expression is considered highly selective for Th2 lymphocytes.

Purpose of the Study:

  • To investigate CRTH2 expression on T cells in the blood and bronchoalveolar lavage (BAL) of asthmatic and normal individuals.
  • To determine the association of CRTH2 expression with specific T cell subsets (IL-4+/IL-13+ vs. IFN-gamma+).

Main Methods:

  • Flow cytometry was employed to quantify CRTH2 expression on T cells.
  • Analysis was performed on peripheral blood and BAL samples from asthmatic and healthy subjects.
  • T cell subsets were identified based on cytokine production (IL-4, IL-13, IFN-gamma).

Main Results:

  • CRTH2 expression was found on a small percentage of T cells in both blood and BAL fluid.
  • CRTH2+ T cells were significantly enriched on IL-4+/IL-13+ T cells compared to IFN-gamma+ T cells in both blood and BAL.
  • A significantly higher proportion of CRTH2+ T cells was observed in the BAL of asthmatics compared to normal subjects.
  • No increase in CRTH2+ T cells was detected in the BAL compared to peripheral blood within asthmatic individuals.

Conclusions:

  • CRTH2 is preferentially expressed on IL-4+/IL-13+ T cells, but their low numbers suggest a limited role in asthma pathogenesis.
  • CRTH2 antagonism may not be an effective strategy for reducing T cell accumulation in the asthmatic lung.