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Related Experiment Video

Updated: Jun 12, 2026

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

Synchronous radiation-induced orbital meningioma and multiple cavernomas.

Nirosha Paramanathan¹, Kenneth Gek-Jin Ooi, Dianne Reeves

¹Department of Ophthalmology, Prince of Wales Hospital, Barker Street, Randwick, NSW 2031, Australia. nirosha.paramanatha@bigpond.com

Clinical & Experimental Ophthalmology

|May 25, 2010

Summary

Synchronous radiation-induced tumors are rare. This case highlights the long-term risks of childhood radiotherapy, showing multiple tumors 16 years after treatment.

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Published on: June 28, 2024

Area of Science:

Neuro-oncology
Radiation Oncology
Pediatric Oncology

Background:

Radiotherapy is a common treatment for pediatric brain tumors.
Secondary malignancies can arise years after radiation exposure.
Synchronous tumors are exceptionally uncommon.

Observation:

A five-year-old received ionizing radiation therapy for parietal anaplastic ependymoma.
Sixteen years post-treatment, the patient developed multiple synchronous tumors.
These included an orbital meningioma and cavernomas in the cerebellum and bilateral basal ganglia.

Findings:

This is the first reported case of synchronous radiation-induced orbital meningioma and cerebellar/basal ganglia cavernomas.
The tumors appeared 16 years after initial radiation therapy.
The findings suggest a potential link between childhood radiotherapy and specific secondary tumor types.

Implications:

This case underscores the significant long-term risks associated with radiotherapy in children.
It emphasizes the need for vigilant long-term surveillance in pediatric cancer survivors.
Further research is warranted to understand the mechanisms of radiation-induced secondary tumors in children.