Related Experiment Video
Updated: Jun 12, 2026
09:53
Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
Published on: July 5, 2021
Synchronous radiation-induced orbital meningioma and multiple cavernomas
Nirosha Paramanathan1, Kenneth Gek-Jin Ooi, Dianne Reeves
1Department of Ophthalmology, Prince of Wales Hospital, Barker Street, Randwick, NSW 2031, Australia. nirosha.paramanatha@bigpond.com
Clinical & Experimental Ophthalmology
|May 25, 2010
Summary
Synchronous radiation-induced tumors are rare. This case highlights the long-term risks of childhood radiotherapy, showing multiple tumors 16 years after treatment.
Area of Science:
- Neuro-oncology
- Radiation Oncology
- Pediatric Oncology
Background:
- Radiotherapy is a common treatment for pediatric brain tumors.
- Secondary malignancies can arise years after radiation exposure.
- Synchronous tumors are exceptionally uncommon.
Observation:
- A five-year-old received ionizing radiation therapy for parietal anaplastic ependymoma.
- Sixteen years post-treatment, the patient developed multiple synchronous tumors.
- These included an orbital meningioma and cavernomas in the cerebellum and bilateral basal ganglia.
Findings:
- This is the first reported case of synchronous radiation-induced orbital meningioma and cerebellar/basal ganglia cavernomas.
- The tumors appeared 16 years after initial radiation therapy.
- The findings suggest a potential link between childhood radiotherapy and specific secondary tumor types.
Implications:
- This case underscores the significant long-term risks associated with radiotherapy in children.
- It emphasizes the need for vigilant long-term surveillance in pediatric cancer survivors.
- Further research is warranted to understand the mechanisms of radiation-induced secondary tumors in children.
Related Concept Videos
01:27Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
01:19Cranial and Spinal Meninges
The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
01:18Viral Meningitis
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...