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Prevalence of Helicobacter pylori positivity in patients undergoing percutaneous coronary intervention

C Hiew1, A Duggan, T de Malmanche

  • 1Cardiovascular Unit, John Hunter Hospital, University of Newcastle, Newcastle, New South Wales, Australia.

Internal Medicine Journal
|May 25, 2010
PubMed

Insights

Helicobacter pylori infection is present in 37% of patients undergoing percutaneous coronary intervention (PCI). This infection may increase the risk of gastrointestinal bleeding in patients receiving antiplatelet therapy after PCI.

Area of Science:

  • Cardiology
  • Gastroenterology
  • Infectious Disease

Background:

  • Haemorrhagic complications after percutaneous coronary intervention (PCI) significantly impact patient outcomes.
  • Helicobacter pylori (H. pylori) infection is a known cause of peptic ulcer disease, particularly in patients using non-steroidal anti-inflammatory drugs.
  • The prevalence of H. pylori in patients undergoing PCI and receiving antiplatelet therapy is not well-documented.

Purpose of the Study:

  • To determine the prevalence of H. pylori positivity in patients undergoing PCI.
  • To identify features associated with H. pylori positivity in this patient group.

Main Methods:

  • A cohort of 245 patients undergoing PCI between August 2008 and April 2009 were identified.
  • H. pylori positivity was assessed using a commercially available enzyme-linked immunosorbent assay (ELISA) for serological status.

Main Results:

  • 37% of patients (91 out of 245) tested positive for H. pylori serology.
  • A significant proportion (75%) of H. pylori positive patients were on medications known to increase gastrointestinal bleeding risk.
  • H. pylori positive patients were generally older and had higher creatinine levels, often receiving proton pump inhibitor therapy.

Conclusions:

  • H. pylori positivity was detected in 37% of an unselected PCI cohort, representing a potential, treatable cause of bleeding.
  • This prevalence suggests H. pylori is a significant factor for patients on dual antiplatelet therapy post-PCI.
  • Further research is needed to establish the link between H. pylori positivity and adverse gastrointestinal and cardiac outcomes.
Abstract

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