Natural antioxidants protect against cadmium-induced damage during pregnancy and lactation in rats' pups

Free-radicals production is involved in the toxicity of cadmium. The aim of this study was to determine whether biochemical changes occurred in the liver and kidney of cadmium exposed pups during gestation and lactation, and additionally to investigate the potential beneficial role of the administration of certain antioxidants against cadmium exposure damage. Pregnant Wistar rats received the following treatments as drinking water: (1) Distilled water; (2) Cadmium (10 mg/L); (3) Cadmium + Zinc (20 mg/L) + vitamins A (50000 U/L), C (2 g/L), E (500 mg/L), and B(6) (500 mg/L); (4) Vitamins + Zinc solution. We found an increase in hemolysis and in the aminolevulinic acid dehydratase (delta-ALAD) activity in the erythrocytes among both cadmium-exposed groups. Cadmium exposure increased the production of thiobarbituric acid reactive substances (TBARS), catalase, and alkaline and acid phosphatase activity in both the organs studied. The effect on the enzymatic activity was reduced by the coadministration of vitamins and zinc. Our findings suggest that administration of antioxidants during gestation and lactation could prevent some of the negative effects of cadmium.