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Published on: June 7, 2016
Gene expression profiles and microsatellite instability in uterine corpus endometrioid adenocarcinoma
Yasuko Koyamatsu1, Masaru Sakamoto, Kiyohiko Miyake
1Department of Gynecology, Sasaki Foundation Kyoundo Hospital, 1-8, Kandasurugadai, Chiyodaku, Tokyo 101-0034, Japan. y.koya@t-t-t.jp
Aim:
We examined corpus cancer to identify whether there are distinctive patterns of global gene expression and microsatellite instability, and to gain molecular understanding of its carcinogenesis and progression.
Methods:
Thirty endometrioid corpus cancer tissue samples (21 of G1 and nine of G2/3) were analyzed by cDNA microarray based on 637 cancer-associated genes and by a polymerase chain reaction method for microsatellite instability.
Result:
Of the 30 cases, 10 (33%) were recognized as having microsatellite instability. In all cases, four genes were overexpressed and five genes were underexpressed. There were six microsatellite instability-specific overexpressed or high-frequency genes and 15 underexpressed or low-frequency genes. Furthermore, we identified several genes by grade analysis.
Conclusions:
These results may be useful resources for the development of diagnostic assays, prognostic factors, or therapeutic targets for corpus endometrioid cancer.