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Related Experiment Videos

Ultrasound contrast agents.

R Schlief1

  • 1Clinical Research Diagnostics, Schering AG, Berlin, FRG.

Current Opinion in Radiology
|April 1, 1991
PubMed
Summary

New ultrasound contrast agents, utilizing microbubble stabilization, show safety and efficacy for improved vascular imaging and diagnostics. These agents offer broad potential applications in various medical imaging procedures.

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Area of Science:

  • Medical Imaging
  • Diagnostic Ultrasound
  • Biomedical Engineering

Background:

  • Microbubble stabilization is crucial for developing effective ultrasound contrast agents.
  • Two key concepts, albumin microencapsulation (Albunex) and saccharide microparticles (SH U 454), have emerged for contrast agent production.
  • Transpulmonary stability of agents after intravenous injection is a critical factor for clinical utility.

Purpose of the Study:

  • To evaluate the safety and efficacy of novel ultrasound contrast agents.
  • To explore the potential of these agents in enhancing vascular Doppler examinations.
  • To assess the diagnostic capabilities of ultrasound contrast agents in various clinical applications.

Main Methods:

  • Development of microbubble stabilization techniques, including albumin microencapsulation and saccharide microparticle formation.
  • Clinical studies evaluating transpulmonary agents (e.g., SH U 508 A).
  • Application of contrast-enhanced ultrasound for vascular Doppler, fallopian tube patency assessment, and organ perfusion imaging.

Main Results:

  • Industrially manufactured contrast agents with reproducible quality have been developed.
  • Clinical studies confirmed the safety and efficacy of transpulmonary ultrasound contrast agents.
  • Demonstrated improvements in vascular Doppler examinations and feasibility of organ perfusion imaging.

Conclusions:

  • Ultrasound contrast agents represent a significant advancement in diagnostic sonography.
  • These agents offer a broad spectrum of potential indications, enhancing diagnostic capabilities.
  • Further improvements in vascular Doppler examinations are anticipated with these new tools.

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