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Palmoplantar keratoderma as the initial sign in a peripheral T-cell lymphoma
Wendi E Wohltmann1, Daniel M MacAlpine, Darryl Shaw Hodson
1Wilford Hall Medical Center, San Antonio, Texas, USA. wwohltmann@hotmail.com
Dermatology Online Journal
|May 25, 2010
Summary
A rare case of peripheral T-cell lymphoma presented initially as severe palmoplantar keratoderma in a 27-year-old male. This finding highlights the importance of considering systemic diseases in skin conditions.
Area of Science:
- Dermatology
- Oncology
- Hematology
Background:
- Palmoplantar keratoderma (PPK) is a skin condition affecting the palms and soles.
- Peripheral T-cell lymphoma (PTCL) is a group of aggressive cancers originating from T-lymphocytes.
Observation:
- A 27-year-old male presented with acquired, severe, and diffuse palmoplantar keratoderma.
- This skin manifestation was the first noticeable sign of his illness.
Findings:
- The patient was diagnosed with peripheral T-cell lymphoma.
- The severe PPK was identified as the initial presenting symptom of PTCL.
Implications:
- This case underscores the potential for unusual skin presentations of hematologic malignancies.
- Early recognition of severe PPK may aid in the timely diagnosis of PTCL.
- Highlights the need for a multidisciplinary approach in diagnosing complex cases involving skin and systemic disease.
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