Related Experiment Video

Updated: Jun 12, 2026

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
08:19

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

[Etanercept and neoplasms]

A García-Rabasco1, J L Sánchez-Carazo, A Esteve

  • 1Servicio de Dermatología, Consorcio Hospital General Universitario, Valencia, España. anagrabasco@gmail.com

Actas Dermo-Sifiliograficas
|May 25, 2010
PubMed

Insights

Tumor necrosis factor (TNF) blockers significantly advance inflammatory disease treatment but may increase neoplasm risk. A psoriasis patient developed breast cancer after etanercept, highlighting this debated adverse effect.

Area of Science:

  • Immunology
  • Oncology
  • Dermatology

Background:

  • Tumor necrosis factor (TNF) blockers represent a therapeutic advance for inflammatory diseases like psoriasis.
  • TNF is crucial for immune surveillance against infections and neoplasms.

Observation:

  • A long-standing psoriasis patient developed breast adenocarcinoma following etanercept treatment.
  • This case highlights a potential adverse effect of anti-TNF therapy.

Findings:

  • The use of anti-TNF agents, including etanercept, is debated regarding an increased risk of neoplasm development.
  • Literature suggests associations between anti-TNF therapy and certain cancers, such as leukemias, lymphomas, and solid tumors.

Implications:

  • Clinicians should carefully weigh the benefits and risks of anti-TNF therapy in patients with inflammatory conditions.
  • Further research is warranted to elucidate the precise relationship between anti-TNF agents and neoplasm risk.

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