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Updated: Jun 12, 2026

Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures
Published on: March 20, 2019
Myelin-associated glycoprotein and myelin basic protein are present in central and peripheral nerve myelin throughout
J M Matthieu1, T V Waehneldt, N Eschmann
1Laboratoire de Neurochimie, Service de Pédiatrie, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland.
Abstract:
This phylogenetic study of central and peripheral nervous system myelin proteins demonstrates that important changes occur in the composition of certain myelin proteins during evolution. Only two components, myelin basic protein (MBP) and myelin-associated glycoprotein (MAG) are present in all Gnathostomata representatives investigated. While MBP components varied considerably even among the representatives of a given order, the apparent molecular weight of MAG showed little variation indicating that the conservation of the molecular structure could be important for the function of MAG in glia axon interactions.
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