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Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...

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Expression of N-CAM polypeptides in neurons.

O Nybroe1, A Gibson, C J Møller

  • 1The Protein Laboratory, University of Copenhagen, 34 Sigurdsgade, DK-2200 Copenhagen N, Denmark.

Neurochemistry International
|May 25, 2010
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Neurons can synthesize the N-CAM C-polypeptide, contrary to previous beliefs. This finding suggests both neuronal and glial cells contribute to developmental changes in neural cell adhesion molecule expression.

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Developmental Biology

Background:

  • Neural Cell Adhesion Molecule (N-CAM) exists in three polypeptide forms (A, B, C) in rat brain.
  • Cultured neurons were previously thought to express only N-CAM A and B, while glial cells express B and C.
  • The increasing biosynthesis of N-CAM C during postnatal development suggested neuronal differentiation or increased glial contribution.

Purpose of the Study:

  • To investigate the expression of N-CAM polypeptides in neurons.
  • To determine if neurons are capable of synthesizing the N-CAM C-polypeptide.
  • To clarify the cellular sources of developmentally regulated N-CAM C expression.

Main Methods:

  • Biosynthetic labeling of cultured peripheral ganglia and adrenal chromaffin cells.
  • Cell-free translation of microsomes from neuronal cultures.
  • In vivo biosynthetic labeling of retinal ganglion neurons in rats.

Main Results:

  • Cultured neurons synthesized N-CAM A, B, and C, although C production capacity was low.
  • Neuronal microsomes contained messenger RNA encoding for the N-CAM C-polypeptide.
  • Retinal ganglion neurons expressed N-CAM C in their natural environment in vivo.

Conclusions:

  • Neurons possess the capability to synthesize the N-CAM C-polypeptide.
  • Both neurons and glial cells may contribute to the developmental regulation of N-CAM C expression.
  • The study revises the understanding of N-CAM expression patterns in neuronal development.