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Updated: Jun 12, 2026

Fat-Water Phantoms for Magnetic Resonance Imaging Validation: A Flexible and Scalable Protocol
Published on: September 7, 2018
MRI estimation of gadolinium and albumin effects on water proton
Hassan Bagher-Ebadian1, Ramesh Paudyal, Tavarekere N Nagaraja
1Department of Neurology, Henry Ford Hospital, Detroit, MI, USA. ebadian@neurnis.neuro.hfh.edu
Abstract:
The longitudinal relaxivity on the protons of water of a Gd-chelate-albumin compound was measured at 7 T as a function of the macromolecular content of a cross-linked matrix. In agreement with previous works, the results demonstrate that the effect of gadolinium on water proton relaxivity is not constant, rising moderately with increase in the concentration of bovine serum albumin (BSA). About 35% variation in relaxivity was observed over a 0%-25% range of BSA concentrations (ℜ = 3.893 + 0.0502 × BSA [%], SE = 0.0119 and 0.1740, t = 4.215 and 22.383, p < 0.014 and 0.001).
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