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Related Concept Videos

Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
Spinal Cord01:26

Spinal Cord

The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.
Spinal Cord: Cross-sectional Anatomy01:16

Spinal Cord: Cross-sectional Anatomy

The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

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Related Experiment Video

Updated: Jun 12, 2026

In Vivo Telemetry to Record Long-Term Cardiovascular Parameters, Temperature, and Activity in Spinal Cord Injury Rat Models
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In Vivo Telemetry to Record Long-Term Cardiovascular Parameters, Temperature, and Activity in Spinal Cord Injury Rat Models

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Aging with spinal cord injury.

Susan Charlifue1, Amitabh Jha, Daniel Lammertse

  • 1Research Department, Craig Hospital, 3425 South Clarkson Street, Englewood, CO 80113, USA. susie@craighospital.org <susie@craighospital.org>

Physical Medicine and Rehabilitation Clinics of North America
|May 25, 2010
PubMed
Summary

Aging individuals with spinal cord injuries face secondary health conditions impacting independence and community integration. This review details age-related issues and interventions for this population.

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Area of Science:

  • Gerontology
  • Rehabilitation Medicine
  • Neuroscience

Background:

  • Spinal cord injury (SCI) survivors are living longer, leading to an increased prevalence of age-related health issues.
  • These secondary conditions can significantly impair physical function and community participation in aging SCI populations.
  • Understanding these challenges is crucial for maintaining quality of life in long-term SCI survivors.

Purpose of the Study:

  • To systematically review the health issues encountered by individuals with spinal cord injuries as they age.
  • To describe age-related changes in body systems and their impact on physical independence.
  • To explore alterations in community participation and perceived quality of life in this demographic.

Main Methods:

  • Literature review synthesizing emerging research on aging with spinal cord injury.
  • Clinical experience-based insights into age-related secondary conditions.
  • Body system-by-body system analysis of health challenges.

Main Results:

  • Aging with SCI presents a spectrum of secondary conditions affecting cardiovascular, respiratory, musculoskeletal, and integumentary systems.
  • Diminished physical independence and altered community integration are common sequelae of aging in SCI.
  • Perceived quality of life may be negatively impacted by these age-related changes.

Conclusions:

  • Proactive management and targeted interventions are necessary to mitigate the effects of aging in individuals with spinal cord injuries.
  • Further research is needed to develop and validate strategies for promoting healthy aging in this population.
  • Maintaining physical function and community engagement is key to enhancing the quality of life for aging SCI survivors.