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Altered fractionation in radiotherapy: from radiobiological rationale to therapeutic gain
1University of Oradea, Faculty of Science, Romania. loredana@marcunet.com
Cancer Treatment Reviews
|May 25, 2010
Abstract:
The implementation of altered fractionation schedules in clinical practice came as a need to improve loco-regional control and survival in those cancer patient groups which did not respond satisfactorily to conventionally fractionated radiotherapy. The current review aims to present the radiobiological rationale behind various non-conventional treatment schedules including the encountered challenges, through a compilation of clinical studies/trials and their contribution towards therapeutic gain.
