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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease
R Ramajayam1, Kian-Pin Tan, Hun-Ge Liu
1Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Abstract:
A series of 2-(benzylthio)-6-oxo-4-phenyl-1,6-dihydropyrimidine as SARS-CoV 3CL protease inhibitors were developed and their potency was evaluated by in vitro protease inhibitory assays. Two candidates had encouraging results for the development of new anti-SARS compounds.
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