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Updated: Jun 12, 2026

PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions
Published on: July 27, 2017
Single IB domain (SIBD) protein from Litopenaeus vannamei, a novel member for the IGFBP family
Mónica Castellanos1, Florinda Jiménez-Vega, Francisco Vargas-Albores
1Centro de Investigación en Alimentación y Desarrollo (CIAD). Marine Biotechnology Lab. PO Box 1735, Hermosillo, Son, 83000, Mexico.
Abstract:
Several clones encoding for a peptide similar to insulin-like growth factor protein binding (IGFBP) were found in a Litopenaeus vannamei hemocytes cDNA library. Although IGFBP is constituted by two well defined domains (IB and tyroglobulin) joint by a flexible region; the shrimp transcript encoding only for the IB domain as confirmed by Northern analysis. The expression of this, single IB domain (SIBD)-containing protein is modified by bacteria inoculation suggesting a role in immune response. In addition, shrimp SIBD protein seems to be the common ancestor for the IGFBP superfamily.
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