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Anthelmintic resistance on sheep farms in Wales

E S E Mitchell1, K R Hunt, R Wood

  • 1Veterinary Laboratories Agency (VLA) - Carmarthen, Job's Well Road, Johnstown, Carmarthen SA31 3EZ. s.mitchell@vla.defra.gsi.gov.uk

The Veterinary Record
|May 25, 2010
PubMed
Abstract

No abstract available in PubMed .

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Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
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Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...

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