Related Experiment Video
Updated: Jun 12, 2026

Measuring Nucleotide Binding to Intact, Functional Membrane Proteins in Real Time
Published on: March 11, 2021
Molecular mechanisms in signal transduction at the membrane
1Departments of Chemistry, University of California, Berkeley, California, USA. Jtgroves@lbl.gov
Abstract:
Signal transduction originates at the membrane, where the clustering of signaling proteins is a key step in transmitting a message. Membranes are difficult to study, and their influence on signaling is still only understood at the most rudimentary level. Recent advances in the biophysics of membranes, surveyed in this review, have highlighted a variety of phenomena that are likely to influence signaling activity, such as local composition heterogeneities and long-range mechanical effects. We discuss recent mechanistic insights into three signaling systems-Ras activation, Ephrin signaling and the control of actin nucleation-where the active role of membrane components is now appreciated and for which experimentation on the membrane is required for further understanding.
More Related Videos
08:55Single-Molecule Imaging of Lateral Mobility and Ion Channel Activity in Lipid Bilayers using Total Internal Reflection Fluorescence (TIRF) Microscopy
Published on: February 17, 2023
10:59Visualizing the Conformational Dynamics of Membrane Receptors Using Single-Molecule FRET
Published on: August 17, 2022
Related Concept Videos
Signal Transduction: Overview
Typically, signal transduction involves three...
Amplifying Signals via Second Messengers
Cell-surface Signaling
Amplifying Signals via Enzymatic Cascade
Types of Signaling Molecules
Types of Signaling Molecules