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Related Experiment Video

Updated: Jun 12, 2026

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice

Published on: February 18, 2016

Cannabinoid conditioned reward and aversion: behavioral and neural processes.

Jennifer E Murray¹, Rick A Bevins

¹Department of Psychology, University of Nebraska-Lincoln, Lincoln NE, USA.

ACS Chemical Neuroscience

|May 25, 2010

Summary

This summary is machine-generated.

Delta-9-tetrahydrocannabinol (Δ(9)-THC) and other cannabinoids affect dopamine neurons, influencing reward pathways. Research shows these compounds can produce both rewarding and aversive effects, depending on dosage and experimental conditions.

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Last Updated: Jun 12, 2026

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Area of Science:

Neuroscience
Pharmacology
Addiction Research

Background:

The discovery of delta-9-tetrahydrocannabinol (Δ(9)-THC) as marijuana's primary psychoactive component spurred research into the brain's endogenous cannabinoid system.
Cannabinoid ligands, including Δ(9)-THC, CP 55,940, HU210, and WIN 55,212-2, activate dopamine neurons, impacting reward and addiction-related brain regions.

Purpose of the Study:

To review the conditioned rewarding and aversive effects of cannabinoid ligands using the place conditioning task in rodents.
To analyze how procedural variations in place conditioning studies influence observed outcomes.

Main Methods:

Utilized the place conditioning task in rats and mice to assess the rewarding and aversive properties of cannabinoid ligands.
Reviewed existing literature, noting variations in experimental parameters such as apparatus, dose, conditioning trials, and pre-training drug exposure.

Main Results:

Cannabinoid ligands demonstrated the ability to condition both place preferences (rewarding effects) and place aversions.
Dose-dependent effects were observed, with low doses of Δ(9)-THC showing rewarding effects and higher doses exhibiting aversive properties that can mask or override reward.

Conclusions:

Procedural variations across studies significantly impact the outcomes of cannabinoid place conditioning.
Further research is needed to clarify the complex dose-dependent and context-specific effects of cannabinoids on reward and aversion.