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Published on: February 23, 2014
Invasive pneumococcal disease after implementation of a reduced three-dose pneumococcal conjugate vaccine program: a
Pierre Alex Crisinel1, Isabelle Chevalier, Fabien Rallu
1Infectious Diseases Division, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, 3175 côte Sainte-Catherine, Montréal, Québec, Canada.
Abstract:
Following the implementation of a government-sponsored reduced three-dose (2 + 1) heptavalent conjugate pneumococcal vaccine (PCV7) program, we report a 61.4% decrease in the number of cases of invasive pneumococcal diseases (IPD) treated at our institution. Four years after the implementation of the three-dose reduced vaccine program, only 7.4% of IPD were caused by PCV7 serotypes, and there was an increase in the proportion of IPD caused by nonPCV7 serotypes; serotype 19A represented 40.7% of the strains isolated during the last year of the study. These results, similar to those previously observed with a regular four-dose (3 + 1) PCV7 schedule, are reassuring as to the effectiveness of a reduced three-dose (2 + 1) PCV7 program. Increasing numbers of IPD caused by nonPCV7 serotypes warrant the use of a new conjugate pneumococcal vaccine that contains serotype 19A.
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