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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Related Experiment Video

Updated: Jun 12, 2026

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve

Published on: June 14, 2017

Proteomics for quality-control processes in transfusion medicine.

Angelo D'Alessandro¹, Lello Zolla

¹Department of Environmental Sciences, Tuscia University, Largo dell'Università snc, 01100 Viterbo, Italy.

Analytical and Bioanalytical Chemistry

|May 25, 2010

Summary

Proteomics offers advanced tools for assessing blood product quality, from collection to storage. Despite high costs, this technology is poised for clinical integration to ensure transfusion safety and efficacy.

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A Plasma Sample Preparation for Mass Spectrometry using an Automated Workstation

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Last Updated: Jun 12, 2026

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve

Published on: June 14, 2017

A Plasma Sample Preparation for Mass Spectrometry using an Automated Workstation

A Plasma Sample Preparation for Mass Spectrometry using an Automated Workstation

Published on: April 24, 2020

Area of Science:

Biotechnology
Clinical Chemistry
Hematology

Background:

Recent studies highlight the need for better quality assessment tools for transfusion products.
Proteomics has matured and shows potential for clinical application in transfusion medicine.

Purpose of the Study:

To explore the utility of proteomics for assessing the quality of blood components and plasma derivatives.
To evaluate proteomics as a tool for quality control from collection to storage and for verifying manufacturing processes.

Main Methods:

Application of proteomic strategies for in-depth analysis of blood components.
Utilizing proteomics to investigate protein fractions affected by production and pathogen-reduction processes.
Identifying biomarkers for evaluating blood component integrity and functionality.

Main Results:

Proteomics can be used to test the quality of blood components at various stages.
Proteomic analysis can verify the impact of processing on plasma derivatives and blood components.
Discovery of potential biomarkers for blood component assessment is feasible.

Conclusions:

Proteomics is a promising technology for ensuring the quality and safety of transfusion products.
Wider adoption in clinical practice is currently limited by cost and personnel requirements.
Further development and cost-effectiveness initiatives are needed for routine clinical implementation.