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Mortality in Behçet's disease

D Saadoun1, B Wechsler, K Desseaux

  • 1Hôpital Pitié-Salpétrière, Assistance Publique-Hôpitaux de Paris, and Université Pierre et Marie Curie-Paris 6, Paris, France. david.saadoun@psl.aphp.fr

Arthritis and Rheumatism
|May 25, 2010
PubMed

Insights

Long-term mortality in Behçet

Area of Science:

  • Rheumatology
  • Vasculitis Research
  • Clinical Epidemiology

Background:

  • Behçet's disease (BD) is a rare, chronic inflammatory disorder.
  • Understanding long-term mortality is crucial for patient management.

Purpose of the Study:

  • To determine the long-term mortality rates and causes of death in a large cohort of patients with Behçet's disease.
  • To identify factors associated with increased mortality in BD patients.

Main Methods:

  • Analysis of 817 patients diagnosed with BD according to international criteria.
  • Assessment of mortality causes, standardized mortality ratios (SMR), and multivariate risk factors.
  • Median follow-up of 7.7 years.

Main Results:

  • Overall mortality was 5% (41 deaths) over the follow-up period.
  • Major causes of death included major vessel disease (43.9%), cancer (14.6%), CNS involvement (12.2%), and sepsis (12.2%).
  • Increased mortality was observed in younger adults (15-34 years); male sex, arterial involvement, and frequent disease flares were independent risk factors for mortality.

Conclusions:

  • Behçet's disease carries a significant long-term mortality risk, particularly due to vascular complications.
  • Male sex, arterial disease, and disease activity (flares) are key predictors of mortality in BD patients.
Abstract

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