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[Study on different proportion formulas of activating blood circulation by FTIR]
Mao-Ling Xu1, Hui-Fen Li, Qun Zhou
1Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. baby.mao.mao@hotmail.com
Guang Pu Xue Yu Guang Pu Fen Xi = Guang Pu
|May 26, 2010
Summary
Fourier transform infrared (FTIR) spectroscopy revealed distinct spectral patterns for sargentgloryvine stem, radix paeoniae rubra, and cortex moutan combinations. Formula proportions significantly influence the characteristic absorption bands and potential pharmacodynamic actions.
Area of Science:
- Phytochemistry
- Spectroscopy
- Traditional Chinese Medicine
Background:
- Understanding the chemical interactions within multi-herb formulas is crucial for optimizing their therapeutic efficacy.
- Sargentgloryvine stem, radix paeoniae rubra, and cortex moutan are commonly used in traditional medicine.
Purpose of the Study:
- To investigate the compatibility of sargentgloryvine stem, radix paeoniae rubra, and cortex moutan using spectroscopic methods.
- To analyze how different proportions of these herbs affect their Fourier transform infrared (FTIR) spectra and spectral characteristics.
Main Methods:
- Fourier transform infrared (FTIR) spectroscopy was employed to analyze the herbs and their combined formulas.
- Two-dimensional correlation spectroscopy was utilized to study spectral changes under different formula proportions.
Main Results:
- Distinct regularities in FTIR spectra, second derivative spectra, and synchronous 2D correlation spectra were observed for different formula proportions.
- Characteristic absorption bands for sargentgloryvine stem (1610, 1518, 1446 cm⁻¹) were identified, with the original formula showing stronger peaks.
- The proximity of the 1614 cm⁻¹ band in modified formulas to the sargentgloryvine stem's characteristic band (1610 cm⁻¹) suggests its significant influence.
Conclusions:
- The proportion of drug dosage in herbal formulas can alter the pharmacodynamic actions of the integral formula.
- Spectroscopic analysis provides insights into the compatibility and chemical basis of multi-herb formulations.
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