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Related Experiment Video

Updated: Jun 12, 2026

Using Phage Display to Develop Ubiquitin Variant Modulators for E3 Ligases
06:30

Using Phage Display to Develop Ubiquitin Variant Modulators for E3 Ligases

Published on: August 27, 2021

Phage display applications for molecular imaging.

Jiong Cai1, Zhaofei Liu, Fan Wang

  • 1Department of Nuclear Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China.

Current Pharmaceutical Biotechnology
|May 26, 2010
PubMed
Summary
This summary is machine-generated.

Phage display technology accelerates the development of molecular imaging probes for diagnosing various human diseases, including cancers and neurological conditions. This high-throughput method enables rapid identification of ligands for diverse disease targets.

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Last Updated: Jun 12, 2026

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Area of Science:

  • Biomedical engineering
  • Molecular imaging
  • Drug discovery

Background:

  • Advancements in molecular imaging hardware and disease targets necessitate novel diagnostic probes.
  • Phage display techniques offer high-throughput capabilities for rapid probe development.

Purpose of the Study:

  • To highlight the utility of phage display in developing molecular imaging probes.
  • To showcase the application of phage display for various disease targets.

Main Methods:

  • Utilizing antibody and peptide phage display libraries for ligand selection.
  • Applying phage display techniques for the development of imaging agents.

Main Results:

  • Phage display has been successfully applied to identify ligands for numerous cancer types, including osteosarcomas, pancreatic cancer, and thyroid cancer.
  • The technique is also used for developing agents targeting tumor therapy response, apoptosis, hypoxia, infections, inflammation, Alzheimer's disease, diabetes, and cardiovascular diseases.

Conclusions:

  • Phage display is a powerful and versatile tool for accelerating the development of molecular imaging probes.
  • This technology has broad applications in diagnosing and monitoring a wide range of human diseases.