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Characterization of a strongly immunogenic mouse leukemia line (DL811) undergoing spontaneous cure with tumor
A Matsuzawa1, T Kaneko, Y Takeda
1Laboratory Animal Research Center, University of Tokyo, Japan.
The strongly immunogenic B-cell leukemia line, DL811, was established from a spontaneous leukemia in DDD mice. When 10(6) DL811 cells were s.c. inoculated, all athymic DDD-nu/nu mice died of disseminated leukemia but less than 20% of euthymic DDD mice were spontaneously cured of it. Although cured mice resisted a challenge with 10(7) DL811 cells, they frequently died of relapse. Whole-body gamma-ray irradiation accelerated the relapse of leukemias, implying that leukemic cells can survive against host immune cell killing in a dormant state. L3T4+ Lyt-2+ T cells were suggested to have a significant role in spontaneous cure and maintenance of the dormant state.
The strongly immunogenic B-cell leukemia line, DL811, was established from a spontaneous leukemia in DDD mice. When 10(6) DL811 cells were s.c. inoculated, all athymic DDD-nu/nu mice died of disseminated leukemia but less than 20% of euthymic DDD mice were spontaneously cured of it. Although cured mice resisted a challenge with 10(7) DL811 cells, they frequently died of relapse. Whole-body gamma-ray irradiation accelerated the relapse of leukemias, implying that leukemic cells can survive against host immune cell killing in a dormant state. L3T4+ Lyt-2+ T cells were suggested to have a significant role in spontaneous cure and maintenance of the dormant state.