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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
What is the Skeletal System?01:02

What is the Skeletal System?

Overview

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Related Experiment Video

Updated: Jun 12, 2026

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model
06:59

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model

Published on: September 8, 2023

Male osteoporosis.

Nicole Ducharme1

  • 1Division of Endocrinology, Saint Louis University School of Medicine, 1402 South Grand Boulevard, O'Donnell Hall, 2nd Floor, St Louis, MO 63104, USA. nducharme3@hotmail.com

Clinics in Geriatric Medicine
|May 26, 2010
PubMed
Summary

Osteoporosis affects men later than women and is often linked to low vitamin D and declining testosterone. Bisphosphonates are a primary treatment for male osteoporosis.

Area of Science:

  • Endocrinology
  • Geriatrics
  • Bone Metabolism

Background:

  • Osteoporosis onset typically occurs about a decade later in males compared to females.
  • Low vitamin D levels are a prevalent issue contributing to bone health decline.
  • Decreased testosterone is a significant etiological factor in male osteoporosis.

Purpose of the Study:

  • To summarize the key aspects of osteoporosis in men, including its typical onset, contributing factors, and primary treatment strategies.

Main Methods:

  • Review of current literature on male osteoporosis.
  • Analysis of epidemiological data regarding osteoporosis incidence in males versus females.
  • Evaluation of the role of vitamin D and testosterone in male bone health.
  • Assessment of treatment guidelines for osteoporosis in older men.

Related Experiment Videos

Last Updated: Jun 12, 2026

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model
06:59

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model

Published on: September 8, 2023

Main Results:

  • Male osteoporosis generally manifests later than in females.
  • Vitamin D deficiency is a common comorbidity.
  • Testosterone decline is a critical driver of bone loss in men.
  • Bisphosphonates are established as the preferred therapeutic option for older males with osteoporosis.

Conclusions:

  • Understanding the unique pathophysiology of male osteoporosis is crucial for effective management.
  • Addressing vitamin D deficiency and testosterone decline are important therapeutic considerations.
  • Bisphosphonate therapy offers a proven treatment for established osteoporosis in aging men.