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Role of high augmentation index in spontaneous intracerebral haemorrhage

Hock Keong Lee1, Ab Rahman Izaini Ghani, Mohamed Saufi Awang

  • 1Department of Neuroscience, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.

Asian Journal of Surgery
|May 26, 2010
PubMed

Insights

High augmentation index (AI), a marker of arterial stiffness, independently predicts mortality in patients with intracerebral haemorrhage (ICH). Poor outcome is predicted by Glasgow Coma Scale score, leukocyte count, and haematoma volume.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Stroke Research

Background:

  • Intracerebral haemorrhage (ICH) is a severe stroke type with limited treatment options.
  • Established risk factors for ICH, including hypertension and diabetes, are linked to arterial stiffness.
  • Augmentation index (AI) serves as a surrogate marker for arterial stiffness.

Purpose of the Study:

  • To investigate the prognostic significance of high AI in patients diagnosed with spontaneous ICH.
  • To identify predictors of both poor outcome and mortality following ICH.

Main Methods:

  • A prospective study involving 60 patients with spontaneous supratentorial ICH.
  • Modified Rankin Scale used for 3-month outcome assessment.
  • Logistic regression analysis to determine independent predictors of outcome and mortality.

Main Results:

  • Admission Glasgow Coma Scale score, total leukocyte count, and haematoma volume predicted poor 3-month outcome.
  • High AI (OR, 8.6) and midline shift (OR, 7.5) were independently associated with 3-month mortality.

Conclusions:

  • Glasgow Coma Scale score, leukocyte count, and haematoma volume are significant predictors of poor ICH outcome.
  • High AI and midline shift are significant predictors of mortality in ICH patients.
Abstract

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