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Male-specific metabolism of simvastatin by rat liver microsomes
N Uchiyama1, Y Kagami, Y Saitoh
1Central Research Laboratories, Banyu Pharmaceutical Co., Ltd., Tokyo, Japan.
Chemical & Pharmaceutical Bulletin
|January 1, 1991
Abstract:
Simvastatin was more effectively metabolized by the liver microsomes of male rats than females. The sex difference appeared in the composition of the metabolites. Two male-specific metabolites were identified by NMR and mass spectrometry as 3''-hydroxy and 3',3''-dihydroxy-delta 4',5' derivatives of simvastatin.